Everyone will have to work together to survive and upgrade in the beginning, but as a player gets close to getting their fourth soul things inevitably get treacherous. Players take control of a handful of familiar characters and collect loot, treasures, and fight monsters in an effort to be the first to gain four souls. The Binding of Isaac: Four Souls, is a take-that, semi-cooperative card game for 2-4 players and it has blown well past it's funding goal on Kickstarter already.
This is why it's especially interesting that the game's designer, Edmund McMillen, has been working diligently to translate what some may call his best design into a card game. The success and popularity of Isaac is particularly impressive given it's downright bold use of religious symbolism, gross-out imagery, and body horror that are used to underscore a tragic story of abuse, neglect, and childhood trauma.
It remains one of the greatest examples of a roguelike, harnessing the exploration and excitement of the Legend of Zelda-series with the palpable tension of permanent character death that would leave it's footprint in many games to follow.
Being all-at-once controversial and incredibly influential, The Binding of Isaac paved the way for an entire emergent genre of Video Games.